Prof. Dr. med. Uwe Martens - Onkologie / Hämatologie, Heilbronn - Publikationen

ORIGINAL PUBLICATIONS

1. Telomere elongation in vivo and clinical response to androgen treatment in a patient with aplastic anemia and a heterozygous hTERT gene mutation. Ziegler P, Schrezenmeier H, Akkad J, Brassat U, Vankann L, Panse J, Wilop S, Balabanov S, Schwarz K, Martens UM, Brümmendorf TH. Ann Hematol 91(7):1115-1120, 2012

2. Molecular Biomarkers in non-small-cell lung cancer: results from the phase 3 FLEX study. O’Byrne KJ, Gatzemeier U, Bondarenko I, Barrios C, Eschbach C, Martens UM, Hotko Y, Kortsik C, Paz-Ares L, Pereira JR, Pawel J, Ramlau R, Roh JK, Yu CT, Stroh C, Celik I,  Schueler A, Pirker R. Lancet Oncology 12(8):795-805, 2011

3. Localization and density of immune cells in the invasive margin of human metastatic colorectal cancer are prognostic for response to chemotherapy. Halama N, Michel S, Kloor M, Zoernig I, Benner A, Spille A, Pommerencke T, Knebel Doeberitz M, Folprecht G, Luber B, Feyen N, Martens UM, Beckhove P, Gnjatic S, Schirmacher P, Herpel E, Weitz J, Grabe N, Jäger D. Cancer Res Aug 16, 2011; Epub ahead of print

4. Prevention, diagnosis, therapy, and follow-up of lung cancer: interdisciplinary guideline of the German Respiratory Society and the German Cancer Society. G Goeckenjan, H Sitter, M Thomas, D Branscheid, M Flentje, F Griesinger, N Niederle, M Stuschke, T Blum, KM Deppermann, JH Ficker, L Freitag, AS Lubbe, T Reinhold, E Spath-Schwalbe, D Ukena, M Wickert, M Wolf, S Andreas, T Auberger, RP Baum, B Baysal, J Beuth, H Bickeboller, A Bocking, RM Bohle, I Bruske, O Burghuber, N Dickgreber, S Diederich, H Dienemann, W Eberhardt, S Eggeling, T Fink, B Fischer, M Franke, G Friedel, T Gauler, S Gutz, H Hautmann, A Hellmann, D Hellwig, F Herth, CP Heussel, W Hilbe, F Hoffmeyer, M Horneber, RM Huber, J Hubner, HU Kauczor, K Kirchbacher, D Kirsten, T Kraus, SM Lang, U Martens, A Mohn-Staudner, KM Muller, J Muller-Nordhorn, D Nowak, U Ochmann, B Passlick, I Petersen, R Pirker, B Pokrajac, M Reck, S Riha, C Rube, A Schmittel, N Schonfeld, W Schutte, M Serke, G Stamatis, M Steingraber, M Steins, E Stoelben, L Swoboda, H Teschler, HW Tessen, M Weber, A Werner, HE Wichmann, E Irlinger Wimmer, C Witt, H Worth, German Respiratory Society, and German Cancer Society. Pneumologie 65(1): 39-59, 2011

5. Blastic Plasmacytoid Dendritic Cell Neoplasia (BPDC) in Elderly Patients: Results of a Treatment Algorithm Employing Allogeneic Stem Cell Transplantation with Moderately Reduced Conditioning Intensity. S Dietrich, U Hegenbart, M Andrulis, T Schmitt, F Bellos, UM Martens, J Meissner, A Kramer, AD Ho, and P Dreger. Biol Blood Marrow Transplant, 17(8):1250-4, 2011

6. Identification of a 17-protein signature in the serum of lung cancer patients. RT Sreseli, H Binder, M Kuhn, W Digel, H Veelken, W Sienel, B Passlick, M Schumacher, UM Martens, and S Zimmermann. Oncol Rep 24(1): 263-70, 2010
equal senior authorship 

7. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, Vynnychenko I, Park K, Yu CT, Ganul V, Roh JK, Bajetta E, O'Byrne K, de Marinis F, Eberhardt W, Goddemeier T, Emig M, Gatzemeier U; FLEX Study Team (…U Martens…). Lancet 373(9674):1525-31, 2009

8. Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction. S Zimmermann, ML Biniossek, C Maurer, P Münzer, M Pantic, H Veelken, and UM Martens. Proteomics 9(22):5175-87, 2009

9. Proteomic profiling of tumor cells after induction of telomere dysfunction. S Zimmermann, ML Biniossek, M Pantic, D Pfeifer, H Veelken, and UM Martens. Proteomics  9(3): 521-34, 2009

10. Immunphenotype as Prognostic Factor for Diffuse Large B-Cell Lymphoma in Patients Undergoing Clinical Risk-Adapted Therapy. Veelken H, Dannheim SV, Schulte Moenting J, Martens UM, Finke J, Schmitt-Graeff A. Annals of Oncology 18(5):931-9, 2007

11. Genome-wide analysis of DNA copy number changes in CLL using high-density SNP arrays. Pfeifer D, Pantic M, Skatulla I, Rawluk J, Kreutz C, Martens UM, Fisch P, Timmer J, Veelken H. Blood 109(3):1202-10, 2007

12. Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells. Pantic M, Zimmermann S, El Daly H, Opitz OG, Popp S, Boukamp P, Martens UM. Oncogene 25(32):4413-4420, 2006 

13. Imatinib mesylate as a novel treatment option for hypereosinophilic syndrome: two case reports and a comprehensive review of the literature. Muller AM, Martens UM, Hofmann SC, Bruckner-Tuderman L, Mertelsmann R, Lubbert M. Ann Hematol  85(1):1-16, 2006
equal first authorship

14. The level of telomere dysfunction determines the efficacy of telomerase based therapeutics in cancer therapy. Pantic M, Zimmermann S, Waller CF, Martens UM. Int J Oncol 26:1227-1232, 2005

15. Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. El Daly H, Kull M, Zimmmermann S, Pantic M, Waller CF, Martens UM. Blood Vol 105, No. 4, 1742-1749, 2005

16. On the regenerative capacity of human skeletal muscle. Wernig A, Schäfer R, Knauf U, Mundegar RR, Zweyer M, Högemeier O, Martens UM, Zimmermann S. Artificial Organs, 29(3):192-198, 2005

17. Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling. Satyanarayana A, Greenberg RA, Buer J, Lauber J, Hahn W, Martens U, Zimmermann S, Manns MP, Rudolph KL. Mol Cell Biol 24:5459-5474, 2004 

18. Effects of telomerase modulation in human hematopoietic progenitor cells. Zimmermann S, Glaser S, Ketteler R, Waller CF, Klingmüller U, Martens UM. Stem Cells 22:741-749, 2004

19. Quantitative analysis of mixed chimerism following allogeneic bone marrow transplantation using telomere flow-FISH. Martens UM, Waller CF, Lange W, Finke J. Annals of Hematology 82:416-422, 2003      

20. Lack of telomerase activity in human mesenchymal stem cells. Zimmermann S, Voss M,  Kaiser S, Kapp U, Waller CF, Martens UM. Leukemia 17(6):1146-1149, 2003

21. Telomere maintenance in human B lymphocytes. Martens UM, Brass V, Sedlacek L, Pantic M, Exner C, Guo Y, Engelhardt M, Lansdorp PM, Waller CF, Lange W. British Journal of Haematology 119:810-818, 2002

22. Enhanced Transgene Expression in Primitive Hematopoietic Progenitor Cells and Embryonic Stem Cells Efficiently Transduced by Optimized Retroviral Hybrid Vectors. Ketteler R, Glaser S, Sandra O, Martens UM, and Klingmüller U. Gene Therapy 9(8):477-487, 2002   

23. A highly selective telomerase inhibitor limiting human cancer cell proliferation. Damm D, Hemmann U, Garin-Chesa P, Hauel N, Kauffmann K, Priepke H, Niestroj C, Daiber C, Enenkel B, Guilliard B, Lauritsch I, Müller E, Pascolo E, Sauter G, Pantic M, Martens UM, Wenz C, Lingner J, Kraut N, J. Rettig WJ and Schnapp A. The EMBO Journal 20(24): 6958-6968, 2001 

24. Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Martens UM, Chavez EA, Poon SSS, Schmoor C, and Lansdorp PM. Experimental Cell Research 256(1):291-299, 2000      

25. Philadelphia chromosome-positive cells are equally distributed in AC 133+ and AC133- fractions of CD34+ peripheral blood progenitor cells from patients with CML. Waller CF, Martens UM, and Lange W. Leukemia 13 (9), 1466-1467, 1999  

26. Telomere length measurements using digital fluorescence microscopy. Poon SSS, Martens UM, Ward RW, and Lansdorp PM. Cytometry 36(4), 267-278, 1999

27. Absence or low number of telomere repeats at junctions of dicentric chromosomes. Wan TSK, Martens UM, Tsao SW, Chan LC, and Lansdorp PM. Genes, Chromosomes & Cancer 24:83-86, 1999

28. Signal transduction in platelets from patients with polycythemia vera (Letter). Lange W, Martens UM, Waller CF. N Engl J Med  339(2):127-128, 1998

29. Short telomeres on human chromosome 17p. Martens UM, Zijlmans JMJM, Poon SSS, Dragowska V, Yui J, Chavez EA, Ward RK, and Lansdorp PM. Nature Genetics 18: 76-80, 1998

30. Telomeres in the mouse have large inter-chromosomal variations in the number of  T2AG3 repeats. Zijlmans JMJM, Martens UM, Poon SSS, Raap AK, Tanke HJ, Ward RK, and Lansdorp PM. Proc Natl Acad Sci USA 94:7423-7428, 1997

31. Burkitt-like mutations in the c-myc gene locus in prolymphocytic leukemia. Brennscheidt U, Eick D, Kunzmann R, Martens U, Kientopf M, Mertelsmann R, Herrmann F. Leukemia 8(5):897-902, 1994
        

REVIEWS

1. XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from molecular pathogenesis to targeted therapy in leukemia and solid tumors. Hackanson B, Becker H, Berg T, Binder M, Dierks C, Duque-Afonso J, Lairmore MD, Schäfer HS, Schnitzler M, Zeiser R, Martens U, Mertelsmann R, Lübbert M. Cancer Res. 15;68(14):5512-8, 2008                    
                                                                      
2. Unsicker. Stem cells: established facts, open issues, and future directions. G. Kuhn, O. Brüstle, U. Martens, A. Wobus, K. Cell Tissue Res 331:1-3, 2008                     

3. Telomeres, senescence, and hematopoietic stem cells. S Zimmermann and UM Martens.
Cell Tissue Res 331(1): 79-90, 2008

4. Telomeres and telomerase as targets for cancer therapy. Zimmermann S and Martens UM. Cellular and Molecular Life Sciences (CMLS) 64(7-8):906-21, 2007

5. Telomere dynamics in hematopoietic stem cells. Zimmermann S and Martens UM. Current Molecular Medicine 5:179-185, 2005                                                                  

6. Telomere und Telomerase als Ansatzpunkte neuer Therapieformen in der Onkologie. Martens UM and Waller CF. Dtsch Med Wochenschr 126(42):1171-2, 2001

7. Telomeres and Telomerase. Martens UM. Biomedical Progress 14:37-41, 2001

8. Telomere und Telomerase. Martens UM. Die gelben Hefte 41:60-67, 2001

9. Measurement of telomere length in haematopoietic cells using in situ hybridization techniques. Martens UM, Brass V, Engelhardt M, Glaser S, Waller CF, Lange W, Schmoor C, Poon SSS, and Lansdorp PM. Biochem Soc Trans 28(2): 245-250, 2000

10. Telomerase-Hemmung: Ein neues therapeutisches Konzept in der Onkologie? Martens U und Lange W. Arneimitteltherapie 18. Jg, Heft 12, 387-392, 2000

11. The implication of telomerase and telomere stability for replicative aging and cellular immortality. Engelhardt M, and Martens UM. Oncol Rep 5: 1043-1052, 1998
  

TEXTBOOKS OR CHAPTERS IN TEXTBOOKS

1. Genexpressionsanalysen durch Microarrays. D. Pfeifer, J. Scheele, U. Martens. Das Rote Buch – Hämatologie und Internistische Onkologie. ecomed Verlag 2010, 4. Auflage, S. 86-88

2. Das Rote Buch – Hämatologie und Internistische Onkologie. U. Martens, D.P. Berger, R. Wäsch. Karzinogenese. ecomed Verlag 2010, 4. Auflage, S. 26-29

3. Molekulare Tumorbiologie und Entstehung maligner Neoplasien. U. Martens, D.P. Berger, R. Wäsch. Das Rote Buch – Hämatologie und Internistische Onkologie. ecomed Verlag 2010, 4. Auflage, S. 25

4. Small Molecules in Oncology. Recent Results in Cancer Research. Volume Editor Uwe M. Martens. Springer-Verlag 2010

5. Systemtherapie beim metastasierten kolorektalen Karzinom. M Lindauer, UM Martens. Buchkapitel in Lokoregionäre Tumortherapie. Agileum Verlag. S. 40-47, 2010

6. Gene Expression Analysis using Microarrays. Scheele J, and Martens U. Manual of Hematology and Oncology. P45-46. Springer-Verlag 2008

7. Developmental Therapeutics. Martens U. Manual of Hematology and Oncology. p322-326. Springer-Verlag 2008

8. Senescence signatures of human hematopoietic stem cells. Zimmermann S, Martens UM. Book chapter in: Telomeres and Telomerase in Ageing, Disease, and Cancer (ed. Rudolph KL) Springer Berlin Heidelberg. 141-159, 2008

9. Genexpressionsanalysen durch Microarrays. Scheele J und Martens UM. Das Rote Buch - Hämatologie und internistische Onkologie, ecomed Verlag, 3. Auflage in Vorbereitung

10. Karzinogenese und molekulare Tumorbiologie. Berger D und Martens UM. Das Rote Buch - Hämatologie und internistische Onkologie, ecomed Verlag, 3. Auflage in Vorbereitung

11. Telomeres in the hematopoietic system. Lansdorp PM, Poon S, Chavez E, Dragowska V, Zijlmans M, Bryan T, Reddel R, Egholm M, Bacchetti S, and Martens U. Book chapter in: Telomeres and Telomerase (eds. DJ Chadwick & G Cardew) John Wiley & Sons Ltd., West Sussex, UK, pp 209-222, 1997